Scientific research has demonstrated that in the eye with neovascular AMD too much VEGF is being produced. VEGF stands for vascular endothelial growth factor, which is a substance that promotes epiretinal membrane growth. Anti-VEGF medication, which removes VEGF, must be administrated to block this growth. The first attempts to treat neovascular AMD involved administrating anti-VEGF medication intravenously. However, it turned out that in the case of eye diseases, the medication can be administrated directly into the eye instead of into the whole system. It is not only less burdensome for the patient, but also more effective. Currently, there are three anti-VEGF medicines to treat neovascular AMD available in the market. They include: Avastin (bevacizumab), Lucentis (ranibizumabum) and Eylea (aflibercept).
Avastin – It has been used in ophthalmology for the longest period of time, that is, since 2006. It is a cancer medicine, which was registered to treat cancer of the colon. However, it was proved to be very effective in the treatment for several retinal diseases. Currently, it is not registered as a medicine that can be injected into the eye, but as a one that should be administrated intravenously.
Lucentis – It was especially designed and registered to treat the wet form of AMD. It is a derivative of Avastin produced by the same pharmaceutical company. The mechanism of action and adverse events of Lucentis and Avastin are similar.
Eylea – It is the latest medicine that we use to treat the wet form of AMD. It is also a cancer medicine, which was tried out in ophthalmology. It turned out that it worked very well in the treatment for retinal oedema. The mechanism of action of Eylea is slightly different from the mechanism of action of Avantin or Lucentis and some patients react better to the treatment.
Over the last six years, many clinical trials on anti-VEGF medication have been carried out. Some research has suggested than some medicines are better than others. However, clinical trials carried out on large populations have indicated that all these medicines show similar efficiency and adverse events.
Dr Agnieszka Nowosielska was one of the first ophthalmologists in Poland to treat AMD with intravitreal injections, starting as early as in 2006. Over the last 11 years, she has performed more than 11 000 injections of that kind. Thanks to her broad clinical experience she has developed the most effective, innovative regimen of anti-VEGF medication administration. Anti-VEGF medicines are administrated in many countries around the world. In the United States, every patient diagnosed with wet AMD receives injections every four weeks till the end of his or her life, regardless of their eye condition. In practice, some patients receive more injections than they need. In our Clinic, we do our best to determine the right dose of the medicine for every patient, depending on his or her individual needs, so that the visual acuity may be restored with as few injections as possible.
It should be remembered that neovascular AMD treatment should be continued till the end of patient's life, but too many injections may be harmful. The effectiveness of this method reaches nearly 100%.